Declared in 1801 Pubblica Biblioteca Nazionale (National Public Library), in the December 1802 the government sanctioned the library title to receive the compulsory deposit from the printers of Liguria.
In 1815, with the passage of the Ligurian territories below the Savoy, as "library of the royal university of Genoa" it took again its narrow tie with the university, moreover never lost again.
In 1866, with the last liquidation (abolition) wave of religious congregations, the library further got rich of the conventual libraries, fact that justifies the presence between its current collections of a full-bodied book religious and theological matter core (core of religious and theological matters).